Fresh analysis reveals that individuals who come off new GLP-1 drugs like semaglutide or tirzepatide can put back on lost weight much more quickly than those who end traditional lifestyle plans.
Findings released in a prominent medical journal demonstrates that while overweight people can lose a large proportion of their body weight while using the jabs, the mass comes back at an average rate of nearly a kilo each month upon discontinuation.
"Users buying such drugs need to be cognizant of the risk of fast weight regain when the medication is stopped," cautioned expert Dr. Susan Jebb.
That rate of regain implies a reversion to pre-treatment weight within about 18 months.
Analyzing Treatments
The analysis, which looked at dozens of trials involving over 9,000 of patients, compared the effects of the injectable medications with older methods.
The team note that people who lose weight through dieting usually experience a more gradual creep back—approximately 100 grams monthly—after stopping.
The Reason for the Quick Rebound
Nutrition scientists propose the mode of action of the jabs explains the heightened weight return.
These medications mimic a natural hormone called GLP-1, which moderates feelings of fullness.
"Artificially providing the hormone levels several times higher than the body's typical production might result in the system to produce less of its endogenous GLP-1, and could reduce responsiveness to its effects," explained Dr. Adam Collins, a nutrition expert.
"Withdrawal of this hormone supplement leads to hunger is no longer kept in check, making binge eating much more probable."
A Lifelong Condition?
Medical guidelines recommend the injections for people with obesity-related medical conditions, accompanied by prescribed lifestyle changes.
Professionals say that, considering the likelihood of relapse, the treatment should be considered long-term.
This opinion is reinforced by pharmaceutical companies, who state that the results "highlight the long-term character of excess weight," comparing it to managing conditions like diabetes.
Patient Experiences
People who have stopped the jabs report a sudden return of cravings.
"It felt as if something activating and I was suddenly starving," said a patient.
This challenge is worsened if users have not established permanent dietary or behavioural changes during treatment.
Widespread Adoption
Figures indicate that a significant number of people in the UK have tried these injections in the past year, with demand continuing to grow.
- Use is higher among women compared to males.
- The 40s and 50s demographic shows the greatest usage rates.
- A large proportion obtain the drugs through private healthcare rather than public health services.
In conclusion, experts caution that while these medications are potent agents for weight loss, they are not a magic fix and maintained weight loss hinges on combined lifestyle changes.
